三环类抗抑郁药（国外英文资料）.doc

三环类抗抑郁药（国外英文资料） [summary and classification] Tricyclic antidepressants (TCA) has applied in the treatment of depression since the 60 s, it is used in the treatment of other mental disorders, such as obsessive-compulsive disorder, lack of concentration, panic, fear of disease, chronic pain syndrome, peripheral neuropathy, nocturnal enuresis, anxiety, eating disorders and migraine prevention and aid in the treatment of drug addiction withdrawal treatment, etc. In the United States, doctors prescribe 25 million TCAS a year to treat patients who try to commit suicide, and in 1983, the death of the TCAS was the third in the list of deaths from drug-related deaths. This is the common drug of the psychiatric department, and the emergency department is not familiar with the side effects of TCAS, but once they are overdose or intoxicated, they come to the emergency clinic. After the drug poisoning clinical course is hard to predict, and there is a clear central nervous system and cardiovascular toxicity, so the emergency physicians should grasp its excessive correct diagnosis and treatment. Tricyclic antidepressants, beginning in the late 1950 s used for clinical purposes, curative effect affirmation, is used to treat depression (manic depressive, endogenous depression) with up to 70 ~ 80%; Maintaining treatment also has a role in preventing relapse in depression. But their anticholinergic and heart-related side effects, to some extent, affect their application. Both at home and abroad in the trial production of new fewer side-effects lighter antidepressants, has paid off, such as isoamyl flat, triadimefon, bromobenzene c organism and Ann best spirit, etc., but their positive and negative effects and advantages and disadvantages, are yet to be test of time and practice. Tricyclic antidepressant amitriptyline, doxepin, imipramine and chlorine imipramine, first choice for treatment of depression, has been basically replace electricity spasm treatment of depression. Tricyclic