不同辅助化疗对乳腺癌术后无病存活期及耐受性影响比较.pdf

• 126 窑 西南国防医药2017年 2 月第27卷第2 期 不同辅助化疗对乳腺癌术后无病存活期及耐受性影响比较 乐 浩 ，许 斌 摘要「 1 目 的 比较不同辅助化疗对可手术乳腺癌患者无病存活期及耐受性的影响。方 法 以本院确诊的104例可手术乳 腺癌患者为研究对象，随机分为两组，行 TA C 辅助化疗6 0 例作为TA C 组，行 FA C 辅助化疗4 4 例作为 FA C 组，比较两组近期 疗效、毒副反应及手术情况。随访3 年，比较两组局部复发、远处转移及无病生存期。结 果 TA C 组近期缓解率(86.7%)显著髙于 FA C 组(6 8 .2% )(P 0.05) 。TA C 组白细胞减少芋~ 郁级发生率明显髙于FA C 组 (P 0.05 )，两组间其他毒副反应无统计学差异 (P 0.05) 。两组保乳切除术构成比无统计学差异(P 0.05) 。随访期间，TA C 组远处转移率(10.0% )显著低于FA C 组 (25.0%) ( P 0 .0 5 );两组局部复发、无病存活期无统计学差异( P 0.05 )。结 论 TA C 化疗方案较FA C 化疗方案近期缓解率明显提髙， 远处转移率显著降低，但无病存活期方面无显著差异。虽 TA C 化疗方案不良反应较F A C 多，但多可控、且耐受性较好。 关键词「 1 乳腺癌; 辅助化疗; 无病存活期;耐受性 中图分类号 R 730.53 文献标识码 A 文章编号 1004-0188(2017)02-0126-03 doi :10.3969/j.issn.1004-0188.2017.02.007 Effects of different adjuvant chemotherapy on disease-free survival and tolerance in patients with bieast cancer Le Hao, Xu Bin Section I of Department of General Surger^^, Enshi National Hospital, Enshi, Hubei, 445000, China ^「^ tractl Objective To compare the effects of different adjuvant chemotherapy on disease-free survival and tolerance in patients with operable breast cancer. MeAods A total of 104 patients with operable breast cancer were selected as the research subjects and were randomly divided into two groups to receive TAC adjuvant chemotherapy (TAC group, n =60) and FAC adjuvant chemotherapy (FAC group, n=44). The clinical efficacy, adverse reaction and operation between the two groups were compared. After three years follow-up visit, the local recurrence, distant metastasis and disease-free survival between the two groups were compared. Results The short-term remission rate (86.7%) in TAC group was significantly higher than that in group FAC (68.2%) (P 0.05). The incidence rate of Grade 芋-郁 level w