Characteristics of Hodgkin’s Lymphoma after Infectious Mononucleosis.pdfVIP

The new england journal of medicine original article Characteristics of Hodgkin’s Lymphoma after Infectious Mononucleosis Henrik Hjalgrim, M.D., Johan Askling, M.D., Klaus Rostgaard, M.Sc., Stephen Hamilton-Dutoit, F.R.C.Path., Morten Frisch, M.D., Jin-Song Zhang, M.D., Mette Madsen, M.Sc., Nils Rosdahl, M.D., Helle Bossen Konradsen, M.D., Hans H. Storm, M.D., and Mads Melbye, M.D. abstract background From the Departments of Epidemiology Infectious mononucleosis–related Epstein–Barr virus (EBV) infection has been associ- Research (H.H., K.R., M.F., M. Melbye) ated with an increased risk of Hodgkin’s lymphoma in young adults. Whether the as- and Respiratory Infections, Meningitis, sociation is causal remains unclear. and STDs, Microbiology, and Diagnostics (H.B.K.), Statens Serum Institut; the Dan- ish Institute for Public Health (M. Madsen); methods the Medical Office of Health, City of Copen- hagen (N.R.); and the Department of Can- We compared the incidence rates of Hodgkin’s lymphoma in two population-based cer Prevention and Documentation, Danish Danish cohorts of patients who were tested for infectious mononucleosis: 17,045 with Cancer Society (H.H.S.) — all in Copen- serologic evidence of having had acute EBV infection, and 24,614 with no such evidence. hagen, Denmark; the Clinical Epi