原发中枢 评分系统.pdfVIP

Prognostic Scoring System for Primary CNS Lymphomas: The International Extranodal Lymphoma Study Group Experience By Andre´s J.M. Ferreri, Jean-Yves Blay, Michele Reni, Felice Pasini, Michele Spina, Achille Ambrosetti, Antonello Calderoni, Andrea Rossi, Vittorio Vavassori, Annarita Conconi, Liliana Devizzi, Franc¸oise Berger, Maurilio Ponzoni, Bettina Borisch, Marianne Tinguely, Michele Cerati, Mario Milani, Enrico Orvieto, Juvenal Sanchez, Christine Chevreau, Stefania Dell’Oro, Emanuele Zucca, and Franco Cavalli Purpose: To identify survival predictors and to design a patients for which complete data of all five variables were prognostic score useful for distinguishing risk groups in immu- available. The 2-year overall survival (OS) SD was 80% nocompetent patients with primary CNS lymphomas (PCNSL). 8%, 48% 7%, and 15% 7% (P .00001) for patients with Patients and Methods: The prognostic role of patient-, zero to one, two to three, and four to five unfavorable fea- lymphoma-, and treatment-related variables was analyzed tures, respectively. The prognostic role of this score was con- in a multicenter series of 378 PCNSL patients treated at 23 firmed by limiting analysis to assessable patients treated with cancer centers from five different countries. high-dose methotrexate-based chemotherapy (2-year OS Results: Age more than 60 years, performance status SD: 85% 8%, 57% 8%, and 24% 11%; P .0004). (PS) more than 1, elevated lactate dehydroge