基于可视人的帕金森病手术靶点核团定位初步研究-第三军医大学学报.doc

基于可视人的帕金森病手术靶点核团定位初步研究 荣晶晶，李七渝，张绍祥，谭立文（400038 重庆，第三军医大学基础医学部解剖学教研室计算医学研究所） ［提要］目的 利用中国首例女性可视人（CVH2）部连续断层图像数据集为帕金森病深部脑电刺激术前的底丘脑核定位。方法 选取CVH2头部连续断层彩色图像并建立标准空间坐标系，通过颅内常用定位标志-前后连合将21例健康成年人头部横断位和冠状位3.0TT2序列图像配准到CVH2标准空间中，利用与毗邻的红核中心坐标来检验配准精度以及该定位方法的可行性。结果 使用该方法定位21例中左右的X、Y、Z坐标平均误差（及标准差）为：X方向上为0.33mm（0.21）、0.40mm（0.25），Y方向上为0.52mm（0.39）、0.44mm（0.36），Z方向上为0.64mm（0.43）、0.64mm（0.41）。经配准后两者红核中心的X、Y、Z坐标值均无显著性差异（P0.05）。结论 利用CVH2头部连续断层图像数据集，经与进行空间配准后对定位与毗邻的红核中心具有较高精度，为帕金森病深部脑电刺激术前的定位提供。 [关键词]可视人；帕金森病；底丘脑核；立体定位 A preliminary research on operation target localization of Parkinson’s disease based on Chinese visible human Rong jingjing，Li qiyu， Zhang shaoxiang，Tan liwen（Department of Anatomy，Chongqing Institute of Computing Medicine，College of Basic Medical Sciences，Third Military Medical University，Chongqing，400038，China） ［Abstract］Objective To develope and validate a new approach for locating operation target of Parkinson’s disease（subthalamic nucleus） based on data set of CVH2 head. Methods Tranverse-section images of head in CVH2 were chosen and a CVH2 stereotactic space was established. Tranverse and coronal T2-weighted magnetic resonance images of the brain（3.0T） were obtained from 21 healthy people using a protocol optimized for nuclei in deep brain visualization. Then using AC and PC as intracranial localization markers to register all MRI sequences into CVH2 stereotacitc space.Accuracy of the registration was tested by comparing centers of bilateral red nuclei（RN） in CVH2 with in MRI. Results After registration，mean deviations were 0.33 and 0.40mm in X；0.52 and 0.44mm in Y；0.64 and 0.64mm in Z with standard deviations of 0.21 and 0.25mm，0.39 and 0.36mm，0.43 and 0.41mm，respectively.There were no significant difference of RN coordinates between registered MRI and CVH2（P0.05）. Conclusion The space registration method based on CVH2 provides an accurate means to locate RN which closes to STN，and can be used for STN localization as an indirect targeting approach. ［Key wo