LP-A2脂蛋白相关磷脂酶A2综述.pdfVIP

Silva et al. Lipids in Health and Disease 2011, 10:170 /content/10/1/170 REVIEW Open Access Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A2 (Lp-PLA2 ): a review * Isis T Silva, Ana PQ Mello and Nágila RT Damasceno Abstract The association of cardiovascular events with Lp-PLA2 has been studied continuously today. The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery was directly related to the hydrolysis of the platelet-activating factor and oxidized phospholipids, which are considered protective functions. However, the hydrolysis of bioactive lipids generates lysophospholipids, compounds that have a pro-inflammatory function. Therefore, the evaluation of the distribution of Lp-PLA2 in the lipid fractions emphasized the dual role of the enzyme in the inflammatory process, since the HDL-Lp-PLA2 enzyme contributes to the reduction of atherosclerosis, while LDL-Lp-PLA2 stimulates this process. Recently, it has been verified that diet components and drugs can influence the enzyme activity and concentration. Thus, the effects of these treatments on Lp-PLA2 may represent a new kind of prevention of cardiovascular disease. Therefore, the association of the enzyme with the traditional assessment of cardiovascular risk may help to predict more accurately these diseases. Keywords: Lp-PLA2 , Cardiovascular risk, antioxidant, pro-inflammatory 1. Introduction such characteristic has assigned to it the first name pla- The physiopathology of cardiovascular disease (CVD) is telet-activating factor acetylhydrolase (PAF-AH) [8]. marked by the presence of atherosclerosis t