冠心病患者辅助性T细胞亚群的变化与意义.PDF

(Ch in H eart J) 2007, 19( 4) # 395# T 韩淑芳, 张 薇, 布 伦, 贾国良 (, 710032) : [( SA) (UA )(AM I) ] T(Th1/Th2) , T 45 13( PBMC) Th1/Th2, ELISA Th1/Th2, Th1/Th2 UA AM I Th1 SA (P 0. 01); Th2; Th1, IFN C IL 2, UA AM I(P 0. 01)Th2 IL 10, IL 4 T (Th1/Th2), IFN C IL 2 : 动脉粥样硬化; 辅助性 T 细胞; 炎症反应 : R541. 4 : A : 1009 7236( 2007) 04 395 04 Dynam ic changes of Th1/Th2 subsets in coronary arterial disease HAN Shu-f ang, ZHAN G We,i BU Lun, J IA Guo-liang ( Department of Cardiology, X ijing H ospita,l Fourth M ilitary M edical University, X ic an 710032, Shaanx,i China) Abstract: AIM To investigate the dynam ic changes ofTh1/Th1 subsets in different phases of coronary + + arterial disease. METHODS W e investigated the peripheral IFN C/CD3 T subsets and IL 4/CD3 T subsets of patientsw ith coronary arterial disease ( CAD) and controls by flow cytometric analysis and T helper 1/T helper2 related cytokines by ELISA. RESU TS T helper 1 cells increased in unstable angina pectoris (UA) and AM I group comparedw ith those in stable angina pectoris ( SA) and controls; T helper 2 cells remained largely unchanged around the tmi e of plaque destabilization; The levels of T helper 1 related cytokines, IFN C and IL 2 were higher inUA and AM I groups than those in SA and control groups. No difference was found in T helper 2 related cytokine, IL 10 bewt een the groups. CONC USION The expansion of T helper subsets is consistent with the advancement of vulnerable plaque. Th1 related cytokines, IFN C and IL 2, contribute to the accelerati