特丁津、双氯芬酸分子印迹聚合物的合成、表征及应用.pdfVIP

Abstract Molecularly imprinted technology is a new-emerging polymerizing technology, which can produces molecule recognition materials with high selectivity. The use of imprinted polymers in several analytical techniques, including liquid chromatography , capillary electrophoresis and capillary electrochromatography, solid phase extraction, mimic biosensors pharmaceutical analysis ，enzyme mimic and immunoassay, have been investigated. In this thesis, diclofenac and terbuthylazine were synthesized by situ polymerization, terbuthylazine synthesized by bulk polymerization. Research on the recognition principium, synthetic conditions ，and the effect to adsorption characteristics of molecularly imprinted polymers. There are four chapters here: Chapter one, The principle of molecular imprinted polymers, application of this technique and its future developments were introduced. Chapter tow, A series of molecularly imprinted monolithic columns were synthesized using terbuthylazine as the template, methacrylic acid (MAA) as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, toluene and dodecanol as the mixed porogenc solvents by in situ thermal-initiated copolymerization technique. The infiuence of porogenic composition, monomer–template ratio and polymerization conditions on the chromatographic performance was investigated. Finally, the recognition performance of the imprinted monolithic column was investigated. Terbuthylazine and its analogues were baseline separated on the monolithic column. The results showed the best ratio of template to functional monomer was l:4，and the toluene content in porogen was 20%. The sep