宫颈锥切术后不孕症患者体外受精―胚胎移植临床探析.docVIP

宫颈锥切术后不孕症患者体外受精―胚胎移植临床探析 　　[摘要]目的 分析宫颈锥切术后不孕症患者体外受精-胚胎移植（IVF-ET）助孕特点及妊娠结局。方法 回顾性分析2012年1月～2014年12月我中心36例宫颈锥切术后不孕症患者（研究组）的IVF-ET方案、实验室指标、妊娠结局，并与同期350例非宫颈锥切术后患者（对照组）进行比较。结果 两组IVF-ET方案、获卵数、受精率、优质胚胎率、新鲜周期移植妊娠率、早期流产率、异位妊娠率比较，差异均无统计学意义（P0.05）；研究组移植胚胎数明显少于对照组（P0.05）。研究组的胎膜早破、早产率、低体重儿比例高于对照组，但差异无统计学意义（P0.05）。结论 宫颈锥切术后不孕症患者IVF-ET助孕特点与其他患者无明显差异，为了减少多胎妊娠，常常会减少移植胚胎数，但不影响妊娠率 [关键词]宫颈锥切；不孕症；体外受精-胚胎移植；妊娠结局 [中图分类号] R714.21 [文献标识码] A [文章编号] 1674-4721（2016）11（c）-0107-04 [Abstract] Objective To examine the effect of cervical conization on in vitro fertilization-embryo transfer （IVF-ET） and pregnancy.Methods The IVF-ET scheme，laboratory index，and pregnancy outcome of 36 patients with cervical conization （study group） from January 2012 to December 2014 in our center were analyzed，and were compared with 350 patients without cervical conization （control group） at the same period.Results There were no statistically significant differences in IVF-ET scheme，the number of retrieved oocytes，and the rate of oocyte-obtained，fertilization，good quality embryo，pregnancy，early abortion，ectopic pregnancy of fresh cycle transplantation between two groups （P0.05）.The number of transferred embryos in the study group was significantly less than that of the control group （P0.05），the rate of premature rupture of membrane，preterm birth，low birth weight children rate in study group was a little higher than that of the control group，but had no statistically significant difference （P0.05）.Conclusion There is no significant difference in IVF-ET protocol between patients with cervical conization and other patients，it would not affect the pregnancy rate using more less of embryos in order to reduce multiple pregnancy. [Key words]Cervical conization；Infertility；IVF-ET；Pregnancy outcome ?m颈上皮内瘤变（cervical intraepithelial neoplasias，CIN）是宫颈浸润癌的癌前病变，发病率呈年轻趋势，很多患者在生育前检出CINⅠ～Ⅲ，而CINⅡ和CINⅢ发展为宫颈癌的风险比CINⅠ增高，常需宫颈锥切术。关于宫颈锥切术对妊娠结局的影响已有很多文献报道。但是关于宫颈锥切术后不孕症患者行体外受精-胚胎移植（in vitro fertilization and embryo transfer，IVF-