支气管肺炎伴血小板增多患儿临床特征及炎症因子变化情况.doc

支气管肺炎伴血小板增多患儿临床特征及炎症因子变化情况 　　[摘要] 目的 观察支气管肺炎伴血小板增多患儿的临床特征和炎症因子的变化情况，为支气管肺炎严重程度监测提供支持。 方法 将河北省秦皇岛市第一医院儿科2015年1～6月收治的198例支气管肺炎患儿根据血小板数量分为研究组和对照组，对两组患儿的血小板计数、炎症因子水平、临床症状和重症肺炎发生率进行观察。 结果 两组发热发生率比较，差异无统计学意义（P=0.271）；研究组喘息、呼吸困难发生率高于对照组，差异有高度统计学意义（P=0.001、0.000）。研究?MC-反应蛋白、白细胞介素-6、肿瘤坏死因子-α水平高于对照组，差异有统计学意义（P=0.031、0.005、0.003）。研究组重症肺炎发生率为36.46%，对照组为18.63%，差异有高度统计学意义（P=0.005）。研究组平均住院天数为（10.52±2.49）d，明显长于对照组的（6.86±2.18）d，差异有统计学意义（P=0.036）。 结论 血小板增多的支气管肺炎患儿炎性反应更重，血小板增多可作为监测支气管肺炎严重程度的指标 [关键词] 支气管肺炎；血小板增多；炎症因子；临床特征 [中图分类号] R563.1 [文献标识码] A [文章编号] 1673-7210（2016）11（b）-0101-04 [Abstract] Objective To observe clinical characteristics and changes in inflammatory factors of children with bronchopneumonia combined with thrombocytosis in order to provide support for bronchial pneumonia severity monitoring. Methods 198 children with bronchopneumonia of Pediatrics Department in the First Hospital of Qinhuangdao City， Hebei Province from January to June 2015 were divided into study group and control group according to their platelets counts. Platelet counts， levels of inflammatory factors， clinical symptoms and the incidence rate of severe pneumonia between two groups were observed. Results The incidence rate of fever between two groups was compared， with no statistical difference （P=0.271）. The incidence rates of breathing， difficulty breathing in study group were higher than those in control group， the differences were highly statistically significant （P=0.001， 0.000）. Levels of C-reaction protein， interleukin-6 and tumor necrosis factor-α in study group were higher than those in control group， the differences were statistically significant （P=0.031， 0.005， 0.003）. The incidence rate of severe pneumonia in study group was 36.46%， the incidence rate of severe pneumonia in control group was 18.63%， the difference was highly statistically significant （P=0.005）. The average hospital stay of study group was （10.52±2.49） d， significantly longer than that of control group [（6.86±2.18）