thyroidcancer甲状腺癌.pptVIP

* First 30 patients with long term data evaluated Male=female, but vast majority are DTC Majority were differentiated thyroid cancer FTC and PTC 4. Few had adriamycin prior to study WHAT’s important is that all of the RAS genes were wild-type -- so it does not seem that an underlying mutation in RAS is the underlying molecular mechanism for the improved PFS seen in FTC-- so what is this mechanism * * 13 patients -- 8WT, 5 BRAF V600E Statistically significant chi-squared p 0.02 WT PFS reached @ 54 weeks V600E PFS not reached * We reported data on 13 patients that showed improved PFS in pts