胆钙化醇(国外英语资料).docVIP

胆钙化醇(国外英语资料) Calcifying bile alcohol Also known as vitamin D3, is the most important 1 forms of vitamin D family, mainly regulating calcium and phosphorus metabolism in the body. Vitamin D is a fat soluble vitamin, a cholesterol substance found mainly in the liver, milk and egg yolks, which is the most abundant in cod liver oil. Vitamin D has two forms, namely vitamin D2, that is, calcium alcohol or ergot calcium alcohol; and vitamin D3, that is, bile alcohol. Vitamin D2 is a kind of plant alcohol, ergosterol (24- methyl -22- dehydrogenation of -7- deoxy cholesterol) to. Ergosterol under ultraviolet light to the intramolecular B ring break into vitamin D2. Vitamin D3 is converted from ultraviolet light from 7- in the skin. Vitamin D3 is a natural form of vitamin D, but not in its biologically active form. Vitamin D is mainly stored in the liver after entering the circulation of the blood. In the liver, vitamin D3 is produced by D3-25- hydroxylase (which requires the presence of NADPH, O2, and Mg2+) to produce 25- dihydroxy vitamin D3 (25-OH-D3). This is the biological effect of vitamin D3 and 3 to 5 times, but when it is not in the physiological dose of physiological function, it also needs further metabolism. 25-OH-D3 from the liver into the blood, and a specific binding globulin in the serum, were transported to the kidney in renal proximal tubular epithelial cells, 25-OH-D3 1 alpha hydroxylase system (including Huang Sumei, iron sulfur protein, cytochrome P-450) role in generating 1,25- hydroxyvitamin D3[1,25- (OH) 2-D3]. 1,25- (OH) 2-D3 is the most effective form of vitamin D3, and its biological effect is about 8~10 times that of vitamin D3. Animals that remove kidneys do not produce 1,25- (OH) 2-D3, so the kidneys are the only site for 25-OH-D3 to do 1 alpha hydroxylation. Because 1,25- (OH) 2-D3 is produced in the kidney and enters the blood circulation, and then plays a physiological effect in distant organs (such as the small intestine and stomach), so 1,2