降钙素基因相关肽(国外英语资料).docVIP

降钙素基因相关肽(国外英语资料) Calcitonin gene-related peptide (CGRP) is expressed by calcitonin Cal/CGRP gene and is a biologically active polypeptide with powerful vasodilator effect. It not only improve hemodynamics, which plays an important role in the systemic blood pressure, blood flow regulation, but also has the effect of antagonizing endothelin -1 (ET-1) vasoconstrictor effect, regulating T and B lymphocyte function, and may be involved in the pathogenesis of endotoxic shock and apoptosis. Keywords calcitonin gene-related peptide; endothelin -1; lymphocyte; The recent studies indicate that vascular endothelial cells and vascular innervation of the nerve endings, can produce a variety of vasoactive substances in the body, they play an important role in the systemic blood pressure and local blood perfusion and cell proliferation regulation. In this review, we reviewed the roles of calcitonin gene-related peptide (Calcitonin, gene, related, peptide, CGRP) in antagonizing ET-1 and immunoregulation. 1 CGRP composition and influencing factors Calcitonin gene-related peptide (Cal), the most potent vasodilator peptide known in vivo, is derived from a common gene associated with calcitonin (Calcitonin). In 1983, Rosenfeld, for the first time, discovered CGRP in mouse medullary thyroid carcinoma C cells using recombinant DNA technology. In 1984, Morris and other human beings proved to have GCRP, confirmed by mouse Cal gene cloning, that Cal and CGRP have the same gene fragments. In humans, Cal/CGRP genes are located on the short arm of chromosome 11, consisting of 6 exons and 5 introns. According to the structure can be divided into CGRP alpha and CGRP beta two categories. CGRP consists of 37 amino acids, the 1 and 7 amino acids of the polypeptide are linked by two sulfur bonds, and the C end is the phenylpropanoid amino acid residue. Human (H) and rat (R) CGRP have 4 amino acids differently, hCGRP alpha and hCGRP beta have 3 amino acids differently, rCGRP alpha and rCGRP beta ha