二十二碳-6烯酸对ADHD儿童临床行为及情绪障碍状况的影响.doc

二十二碳-6烯酸对ADHD儿童临床行为及情绪障碍影响的研究 雷晓梅，杨玉凤*，吕晔，刘灵 （西安交通大学医学院第二附属医院，陕西 西安 710004） 摘要：[目的] 探讨二十二碳-6烯酸（DHA）对注意缺陷多动障碍（attention deficit hyperactivity disorder，ADHD）患儿临床行为及情绪障碍的研究。[方法] 通过对确诊的ADHD儿童补充DHA，分析补充DHA前后ADHD儿童行为及情绪改变的影响。[结果] (1)注意力好转程度、与别人交谈时专心程度、记忆力提高程度在用DHA后有明显改善。在服用DHA前后注意力测试结果不同程度之间比较差异有统计学意义（P=0.000），以重度注意力障碍的儿童改善最明显。(2)治疗后儿童行为问题检出率为12.5%,远低于治疗前的37.9%（P0.01）。6～16岁ADHD男童CBCL行为得分在补充DHA后有所改善（P0.05或0.01）。(3)ADHD儿童在服用DHA前后焦虑性情绪障碍筛查量表得分比较，发现因子躯体化/惊恐、分离性焦虑、广泛性焦虑在用药前后有统计学意义（P0.05）。男童和6～12岁儿童表现最明显。(4)ADHD儿童在服用DHA前后抑郁障碍自评量表得分比较，发现除“对自己有信心”外，其余因子均无统计学意义（P0.05）。[结论] 补充DHA对ADHD患儿临床症状及情绪障碍有一定疗效。 关键词：注意缺陷多动障碍；二十二碳-6烯酸； 行为；情绪障碍 Study on the effect of DoCosahexaenoiC acid with attention deficit hyperactivity disorder in behavioral and emotional change.LEI Xiao-mei,YANG Yu-feng,LV Ye,LIU Ling.(The Second Affiliated Hospital,Medical College of Xi`an Jiaotong University,Xi`an,Shaanxi 710004,China ) Abstract: [Objective] To study the correlation of DoCosahexaenoiC （DHA） with attention deficit hyperactivity disorder(ADHD) in behavioral and emotional change. [Methods] All ADHD children were given DHA of PUFAs and analyze some influention in behavioral and emotional change of ADHD children before and after therapy. [Results] (1)The content of attention, concentration, memory changed well after taking DHA. The results of attention in different degrees were obviously significant before and after taking DHA, and the indexs of the heaviest attention deficit was better than the others.(2)The prevalence of behavioral problems in ADHD children after treatment (12.5%) was obviously lower than before treatment (37.9%)(P0.01). The CBCL indexs of ADHD children aged 6~16 years were improved after treatment (P0.05 or 0.01). (3)There were statistic significance in the SCARED indexs of body/panic, fission anxious, extensive anxious before and after taking DHA. The above indexs in boys and 6~12 years children were obvious.(4)The indexs of DSRSC had no significance in ADHD children