不同治法中药复方对H22肝癌小鼠瘤质量和体质量及免疫功能的影响论文.docVIP

　　不同治法中药复方对H22肝癌小鼠瘤质量和体质量及免疫功能的影响论文 周阿高, 张勇, 蒉纲, 孔德云, 葛海良 任秋华, 董佳容, 洪声, 毛旭明, 王颖, 张惠珍, 王树军 【摘要】 比较不同治法的中药复方对H22肝癌小鼠瘤质量、体质量及免疫功能等的影响。方法：选择移植性肝癌H22小鼠为模型，观察不同治法的中药复方常规水煎剂的抑瘤作用，并通过检测各组小鼠T淋巴细胞增殖功能、自然杀伤细胞（natural killer, NK）杀伤功能、T淋巴细胞表型变化及γ干扰素（interferon-γ, IFN-γ）和白细胞介素-4（interleukin-4,.freelulation index, SI）增加显著（SI=4.34，P 0.01），说明以毒攻毒组小鼠T细胞具有较强的增殖能力；其余各组小鼠SI均低于3.freelor mune function in H22 cancer-bearing mice. Methods: H22 cancer-bearing mice or grophocytes, the activity of natural killer (NK) cells, the changes of T lymphocytes and the content of interferon-γ (IFN-γ）and interleukin-4 (IL-4). Results: Tumor ice in Yidu Gongdu Recipe (YDGDR, a pound traditional Chinese herbal medicine using poison as an antidote for poison)-treated group or inhibition rate in YDGDR-treated group or inhibition rates in other TCCR-treated groups 10.1％ to 17.1%. Body ice in YDGDR-treated group e time. Pelage of mice in Fuzheng Peiben Recipe (FZPBR, a pound traditional Chinese herbal medicine for supporting the healthy energy)-treated group greice ulation index (SI) of T lymphocyte transformation in YDGDR-treated group phocyte phocyte transformation in the other groups phocytes al saline (NS)-treated group, percentages of NK cells in Qinre Jiedu Recipe (QRJDR, a pound traditional Chinese herbal medicine for clearing aedicine for activating blood circulation to dissipate blood stasis)-treated and YDGDR-treated groups es more than the NS-treated group, respectively (P 0.01). The activity of NK cells edicine for eliminating phlegm and resolving masses)-treated and YDGDR-treated groups or grooral immune function in tumor-bearing mice. FZPBR can strengthen the body. Keyethods, traditional Chinese medicine; posite (traditional Chinese drugs); liver cancer; body munity; mice 肿瘤是临床常见病，运用传统中医疗法治疗肿瘤是中国的一大特色。目前中医治疗肿瘤主要分为扶正培本、清热解毒、活血化瘀、化痰散结、以毒攻毒等5种方法，临床医生大多使用其中的一种或几种方法治疗肿瘤，根据文献［1-6］报道，这些方法都有不同程度的临床疗效。由于论文的作者来自不同省市及不同的医疗机构，导致即使是治疗同一癌肿的论文，也很难就其临床疗效作一比较，以确定哪种治疗方法更为有效。本研究以肝癌（H22）小鼠为模型，观察并比较了不同治法的中药复方对肝