Protein degradation and regulation - shutcm - 首 页.pptVIP

Protein Degradation and Regulation Ubiquitin/Proteasome Pathway Guo Peng, Luo Tong and Yang Kong2002.12.16 I. Introduction This pathway is the major non-lysosomal process responsible for the breakdown of most short and long-lived proteins in mammalian cells. For example, in skeletal muscle, the system is responsible for the breakdown of the major contractile proteins, actin and myosins. In addition, the pathway also controls various major biological events: cellcycle progression, oncogenesis, transcriptional control, development and differentiation, signal transduction, re