研究生课程药物基因-3_培训课件.pptVIP

Macrolide Resistance Efflux of drug in S. pyogenes, S. pneumoniae M phenotype encoded by mef gene Alteration of 23S rRNA of 50S ribosomal subunit by methylation of adenine Associated with resistance to macrolides, lincosamides (clindamycin), and streptogramin type B (MLSB phenotype) ermB gene MRSA Resistance to Beta-Lactams Beta-Lactam Modified from David Spach, MD Cell Wall Cell Membrane Alternative Penicillin Binding Protein PBP2a DNA PBP 2a mec A 基因 对B-内酰 胺类耐药 MRSA : MRSA检测方法 NCCLS纸片扩散法或MIC 琼脂筛选法 头孢西丁纸片法 商品化试剂或自动化仪器 mecA基因检测 PBP 2a检测 NCCLS苯唑西林判断标准 纸片法 MIC法