中草药及化学成分对细胞色素CYP3A4影响的研究概况论文.docVIP

　　中草药及化学成分对细胞色素CYP3A4影响的研究概况论文 【摘要】 目的介绍中草药化学成分对细胞色素P3A4亚型影响。方法查阅国内外近年来关于中草药化学成分对细胞色素CYP3A4亚型影响的有关文献并进行综述。结果多种中草药及成分能够抑制或诱导细胞色素CYP3A4亚型，从而影响合用药物的代谢，导致药物相互作用的发生甚至不良反应的发生。结论应重视一些中草药配伍其它药物对细胞色素CYP3A4亚型的影响及所引起的药物相互作用和形成机制的研究，促进临床合理用药，提高中草药的有效性和安全性。 【关键词】 细胞色素P450酶； 中草药； 药物相互作用； 合理用药 Abstract：ObjectiveTo introduce the effect of chemical instituents from Chinese herbal medicine on CYP3A4 isoform of cytochrome P450 system. MethodsTo summarize related literature about Chinese herbal medicine on CYP3A4 isoform of cytochrome P450 system in recent years at home and abroad.ResultsSome Chinese herbal medicine can reduce or induce CYP3A4 isoform of cytochrome P450. Consequently it affected bined drug metabolism and resulted in drug interaction. Conclusionilk thistle, a herbal supplement,.freelan hepatocyte cultures［J］. Drug Metab. Dispos., 2000, 28(11):1270. ［4］Paolini M, Pozzetti L, Sapone A, et a1. Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxy-genases［J］. Life Sci., 1998, 62(6):571. ［5］Budzinski J, Foster B, Vandenhoek S, et al. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected mercial herbal extracts and tinctures［J］. Phytomedicine, 2000, 74:273. ［6］Pekthong D, Martin H, Abadie C, et al. Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide［J］. J. Ethnopharmacol., 2008, 115(3): 432. ［7］贾敬亮，徐丽娜，杜金粱，等. 连翘苷对原代大鼠肝细胞CYP3A1的影响［J］. 黑龙江畜牧兽医, 2008,10:84. ［8］石井贤二, 等. 抑制CYP3A4活性的绿茶成分［J］. 国际中医中药杂志,2006,28(1):49. ［9］Fan L, idazolam in Healthy Volunteers［J］. J Clin Pharmacol, 2006, 46(11):1290. ［11］Liu KH, Kim MJ, Jeon BH, Shon JH, et al. Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba［J］. J. Clin. Pharm. Ther., 2006, 31(1): 83. ［12］Anderson GD, Rosito G, Mohustsy MA, et al. Drug interaction potential of soy extract and Panax ginseng［J］. J. Clin. Pharmacol., 2003, 43(6):643. ［13］Hellum