川大的药化卷子.docVIP

川大的药化卷子(考试用)药学专? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?? ?药物化学课程考试试题（120分钟完成） A:? ? 考试用??B:? ? 补考用 注意： 请在答卷上完成，并和试题卷一起交回！试题卷上的回答不被评阅！每张答卷都必须写上班级、姓名和学号年级：----------? ? ? ? 班：----------? ? ? ? 学号：--------------姓名----------? ? ? ? 一、? ? ? ? 翻译成中文专业英语（共2题，每题5分，共10分，用中文回答为零分）1, 翻译成中文：Lipophilicity represents the affinity of a molecule or?a moiety for?a lipophilic environment. It is commonly measured by its distribution behaviour in a biphasic system, either liquid-liquid (e.g., partition coefficient in octan-1-ol/water) or?solid/liquid (retention on reversed-phase high performance liquid chromatography (RP-HPLC) or?thin-layer chromatography (TLC) system).Efficacy describes the relative intensity with which agonists vary in the response they produce even when they occupy the same number of receptors and with the same affinity. Efficacy is not synonymous to Intrinsic activity. Efficacy is the property that enables drugs to produce responses. It is convenient to differentiate the properties of drugs into two groups, those which cause them to associate with the receptors (affinity) and those that produce stimulus (Efficacy). 2, A bioisostere is a compound resulting from?the exchange of an atom or?of a group of atoms with another, broadly similar, atom or?group of atoms. The objective of a bioisosteric replacement is to create a new compound with similar biological properties to the parent compound. The bioisosteric replacement may be physicochemically or?topologically based 用英语解释：Bioprecursor?prodrug 名词解释并举例说明：（共4题，每题55分,）? ???1，化学治疗药H2受体拮抗剂 ? ? ? ? ? ? ? ? ? ? ? ?? ?2，前药甾类药物? ???3, 质子泵抑制剂COX-2? ?? ?? ?? ?? ?? ?? ?4，抗生素药物靶点三、二、? ? ? ? 简答题：（共3题，每题1010分）? ???1, 青霉素类药物β受体阻滞剂的作用机制分类和各类药物的结构作用特点是什么？2,??简述用乙炔基对雌激素进行修饰的作用。? ???3, 试一药物为例，叙试述抗肿瘤药代谢药物的设计原理的分类和及作用机制，各。举一典型药物。四、A型题（最佳选择题，15题，每题1分，共15分），每题的备选答案中只有一个最佳答案。1.下面哪一项不是前药研究的目的??a. 提高药物的稳定性? ?? ?? ?? ?? ?? ???b. 改变药物的作用靶点减少毒副作用??c.掩蔽药物的不良味道? ?? ?? ?? ?? ???d. 减少毒副作用降低药物成本? ?? ?? ?? ?? ???e.延长药物