和自噬相关的文献.pdfVIP

Neurochemistry International 58 (2011) 301–320 Contents lists available at ScienceDirect Neurochemistry International journal h om epag e: ww /locate/neuint Alzheimer’s disease plaques and tangles: Cemeteries of a Pyrrhic victory of the immune defence network against herpes simplex infection at the expense of complement and inflammation-mediated neuronal destruction C.J. Carter * PolygenicPathways, Flat 4, 20 Upper Maze Hill, Saint Leonard’s on Sea, East Sussex, TN38 0LG, UK A R T I C L E I N F O A B S T R A C T Article history: Plaques and tangles are highly and significantly enriched in herpes simplex (HSV-1) binding proteins (by Received 26 May 2010 11 and 15 fold respectively (P 4.47466E39) and 132/341 (39%) of the known HSV-1 binding partners Received in revised form 30 November 2010 or associates are present in these structures. The classes involved include the majority (63–100%) of the Accepted 1 December 2010 known HSV-1 host protein carriers and receptors, 85–91% of the viral associated proteins involved in Available online 15 December 2010 endocytosis, intracellular transport and exocytosis and 71% of the host proteins associated with the HSV- 1 virion. The viral associated proteins found in plaques or tangles trace out a complete itinerary of the Keywords: virus from entry to exocytosis and the virus also binds to plaque or tangle components invol