磁性纳米载药微球的制备与表征.pdf

制备了5．氟尿嘧啶／壳聚糖纳米磁性微球。通过X射线衍射(XRD)，振动样品磁强计 壳聚糖浓度对微球载药量及包封率的影响，随着5．氟尿嘧啶的加入量的增加，载药量呈 现增大的趋势，当载体材料壳聚糖的浓度增加时包封率先增大后减小。最后我们考察了 药物的释放性能，研究发现磁性壳聚糖载药微球的体外释药曲线可归纳为三个阶段：突 释阶段，扩散阶段，平衡阶段。当制备条件为5．氟尿嘧啶加入量300mg，壳聚糖浓度 4m∥ml时，所得产物微球的药物释放百分率约为92％。对释放曲线进行拟合，发现释 放曲线符合一级释放模型，其拟合方程为：y=30．7．25．47·exp(．0．01256x)。 5．氟尿嘧啶磁性 关键词：纳米载药微球Fe304 JV Abstract consistof andf．r锄ework MagneticdmgnanospheresmagneticnaIlopanicles，drug couldbe localizedtothe of tunnorexternal materials，it selectiVely tragetsite by magnetic fieldandthus“achieVeconcentrationtothecellandreduceundesirabIetoxic highd九Jg haVe receiVedand丽deattentioninthe ef托cts．Therefore，magneticd11Jgnanospheres great neldofcancertreatment． show Currently，althoughmagneticdrug nanospheresspecial onthe treatmentofthe whole leVelofthedomestic adVantagetarget tumor，thedevelopment andabroadstilIliesinthefoud锄entalalsoexistsmuch stage，it put ourresearch on ofthe emphasispreparationsuperiorparticledi锄eter， highmagnetic a themedicinerate． susceptibility，particlescan了inghigh Themaincontentinthis aSfollows： parer 1．The andcharacterizationof preparation IⅥagneticnanoparticles Magnetic were chemical nanoparticlespreparedby co—precipitationprocess．Reactant moIar concentrationof ratio，the molysite，pHValue