Th17细胞及肾小球疾病的研究进展.PDFVIP

中南大学学报（医学版） 2013, 38(4) ; 432 J Cent South Univ (Med Sci) REVIEW · · ·综 述 · DOI:10.3969/j.issn.1672-7347.2013.04.016 /xbwk/fileup/PDF/201304432.pdf Th17 细胞与肾小球疾病的研究进展 周乐天，刘伏友 ( 中南大学湘雅二医院肾脏病研究所，长沙 410011) [ 摘要 ] Th17 细胞是近年来被发现的一种不同于 Th1 和 Th2 细胞的 Th 细胞亚群，它具有独立的分化和调节机制。 Th17 的分化及分泌的 IL-17A(IL-17) 主要受 TGF-β ，IL-6 ，IL-23 和孤儿核受体 (orphan nuclear receptor ，RORγt) 调控。 IL-17A 调节前炎症因子和趋化因子，并介导中性粒细胞的招募。Th17 细胞参与多种肾小球疾病的发病过程。特异性 针对 Th17 细胞或 IL-17A 的治疗可能成为治疗肾小球肾炎的新靶点。 [ 关键词 ] Th17 ；IL-17A ；肾小球肾炎；自身免疫 Research progress of Th17 cells and glomerulonephritis ZHOU Letian, LIU Fuyou (Institute of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China) ABSTRACT T helper (Th) 17 cells are a kind of Th cell subset, and are distinct from the Th1 and Th2 cells and produce interleukin-17A (IL-17A, IL-17). Th17 cells have a mechanism of independent differentiation and developmental regulation. The differentiation and cytokine secretion of Th17 cells are regulated by TGF-β, IL-6, IL-23 and orphan nuclear receptor (RORγt . IL-17 induces ) A pro-inflammatory cytokines and chemokines, mediating neutrophil recruitment. Increasing evidence implicated involvement of Th17 cells in anti-glomerular basement membrane disease,