利培酮及氟哌啶醇治疗老年帕金森伴精神障碍疗效对比探析.docVIP

利培酮及氟哌啶醇治疗老年帕金森伴精神障碍疗效对比探析 　　【摘要】 目的 对比老年帕金森伴精神障碍患者使用氟哌啶醇与利培酮治疗的疗效。方法 100例老年帕金森伴精神障碍患者， 随机分为对照组与观察组， 各50例。观察组患者给予氟哌啶醇治??， 对照组患者给予利培酮治疗。对治疗前后运动功能、精神抑郁、认知能力以及精神障碍程度进行评价， 同时比较用药不良反应发生情况。结果 治疗后， 两组患者的阳性和阴性症状量表（PANSS）评分、简易精神状态量表（MMSE）评分、汉密尔顿抑郁量表（HAMD）评分、统一帕金森病评分分量表（UPDRS）评分均较治疗前改善， 差异均具有统计学意义 （P0.05）。观察组不良反应发生率为12.0%， 对照组不良反应发生率为18.0%， 比较差异无统计学意义（P0.05）。结论 运用氟哌啶醇治疗对老年帕金森伴精神障碍患者的精神障碍以及认知能力改善较利培酮有显著的优势 【关键词】 老年帕金森；精神障碍；利培酮；氟哌啶醇 DOI：10.14163/j.cnki.11-5547/r.2017.06.046 【Abstract】 Objective To compare the curative effect of elderly Parkinson’s disease complicated with mental disorders treated with risperidone and haloperidol. Methods A total of 100 elderly Parkinson’s disease complicated with mental disorders patients were randomly divided into control group and observation group， with 50 cases in each group. The observation group received haloperidol for treatment， and the control group received risperidone for treatment. Evaluation were made on movement function， deprementia， cognitive and psychiatric disorders degree before and after treatment， and occurrence of drug adverse reactions was compared in two groups. Results After treatment， both groups had better positive and negative symptoms scale （PANSS） score， mini-mental state evaluation （MMSE） score， Hamilton depression scale （HAMD） score， unified Parkinson’s disease rating scale （UPDRS） score than before treatment， and the difference had statistical significance （P0.05）. The observation group had incidence of adverse reactions as 12.0%， while the control group had incidence of adverse reactions as 18.0%， and the difference had no statistical significance （P0.05）. Conclusion Implement of haloperidol has significant advantages in mental disorders and cognitive ability improvement than risperidone for the treatment of elderly Parkinsons disease complicated with mental disorders patients. 【Key words】 Elderly Parkinson’s disease； Mental disorders； Risperidone； Haloperidol 帕金森病（Parkinsons disease， PD） 是一种进行性老年