重组人血管抑素K13生物学活性研究.pdf

血管生成有较强的抑制作用，表现为给药区血管密度明显降低，给药的鸡胚发育迟缓等。 鸡胚YSM『】1I管生成模型的建立为与血管生成相关药物的筛选提供了一简便、快速、准确 的体内实验模理。 本实验为重组人血管抑素rhKl—3研制开发和临床应用提供了实验依据。rhKl3具 有较高的抑制ff|L管生成活性，是理想的抗肿瘤药物。一旦投入应用，将使肿瘤治疗水平 上升到一个新的高度。 囊膜 III Abstract ofnew from a vessels，is capillariespre—existing outgrowth complex Angiogenesis．the thatincludesendothelial and cell differention， multistepprocess proliferation．migration ofextracellular ofnew branches． matrices，tube formation，and capillary degradmion sprouting shownthattumor metastatic recent have Several studies invision，and growth，local disseminationareall ontheformationofnewnficrovessels．Theof dependent process is abalancebetween and factors， by angiogenesisregulated pro—angiogenicanti—angiogenic toall isa eventintumor andtheshift aresult， angiogenicphenotypekey progression．As isa new inthe tumor． antiangiogenictherapyhighlypromisingstrategy treatmentof not arrests alsoresultsin Inhibitionof tmnor tumor only gr