干扰素控制结核菌.pdfVIP

I M M U N O L O G Y O R I G I N A L A R T I C L E Interferon-ab mediates partial control of early pulmonary ´ Mycobacterium bovis bacillus Calmette–Guerin infection John Kuchtey,1,4 Scott A. Fulton,2 Summary Scott M. Reba,2 Clifford V. 1 2,3 The role of type I interferon (IFN-ab) in modulating innate or adaptive Harding and W. Henry Boom 1 2 immune responses against mycobacterial infection in the lung is unclear. Institute of Pathology, Division of Infectious 3 In this study we investigated the susceptibility of IFN-ab-receptor-defici- Diseases, and The Tuberculosis Research Unit, Case Western Reserve University and Univer- ent (IFN-abR–/–) mice to pulmonary infection with aerosolized Mycobac- ´ sity Hospitals of Cleveland, Cleveland, Ohio, terium bovis bacillus Calmette–Guerin (BCG). During early infection USA (2–3 weeks), enhanced growth of BCG was measured in the lungs of IFN- abR–/– mice compared to wild-type mice. However, during late infection the burden of BCG was similar in the lungs of IFN-abR–/– and wild-type doi:10.1111/j.1365-2567.2006.02337.x mice. Although control of BCG growth was delayed, recruitment and acti- Received 24 August 2005; revised 13 vation of T and natural killer cells, production of IFN-c, and cytokine December 2005; accepted 4 January 2