肝炎后肝硬化中医证候与疾病信息相似度分析.pdfVIP

398 2009 5 29 5 C JITWM , M ay 2009, V ol. 29, N o. 5 1 2 2 3 1 2, 4 1 苏 越 王 磊 张 华 张 琴 陆奕宇 刘 平 苏式兵 探讨肝炎后肝硬化中医证候与临床症状及 物学指标间的相似性 在对变量进行 归一化处理的基础上,采用夹角余弦相关系数相似度 D及谱图相似度等 4种相似度分析方法对279例肝 炎后肝硬化患者临床表征信息 (症状 ) 物学指标和证候进行相似性分析 获得相应的相似度矩 阵, 以分别反映中医证候和症状与 物学指标之间的相似性, 4种方法得到的结果基本一致, 相似度 D法夹 角余弦法和谱图相似度法与传统的相关系数法相比匹配度显著提高, 灵敏度高取舍定量合理, 方法可靠,较 切合临床实际 通过相似度分析方法所得证候与临床信息间的相似关系与临床实际基本相符该技 术可简化临床指标数量, 为寻找中医证候特征提供简捷可靠的方法 相似度分析;肝炎后肝硬化;证候; 症状; 物学指标 Analysis on S im ilarity between Traditional Chinese Medi ine Syndromes and Information on D isease in Patients w ith Post-hepatitis Cirrhosis SUYue, W ANG Le,i ZHANG Hua, et alResearch Centerf orTraditional Chi- neseM edicine Comp lexity System, Shanghai University of Traditional ChineseM edicine, Shanghai (20120 ) ABSTRACT O bjective To exp lore the smi ilarity between trad itoi nal Chinese med i ine (TCM) syndromes and lin i a lsymptoms and biool g i a l pa rameters in patei nts w ith post-hepatitis irrhosis ( PHC). M ethods Afte r the variants had been norma lized, 4 methods for smi ial rity ana lysis, .i e. method of osine d istan e, orreal toi n oeffi ei n,t D and spe tra l smi ilarity, were used to anayl ze the smi ilarity of lini a l hara teristi informatoi n ( symptoms), b iolog i a l param eters and TCM syndromes obta ined from 279 patients w ith PHC. R esults The orresponding smi ilarity matrixes were used to refel t the smi ilarity between TCM syndromes and symptoms and boi logi al parameters respe tively, results obta ined by the 4 methods were basi ally identi a.l As omparedw ith the traditiona l orreal tion oeffi ei nt ana lysis, the other three methods showed a higher leve lof mat hing, sens-i tiv ity, rationality in quantitative a epting-reje ting and re liability, and were m