社区老年人接种23价肺炎球菌多糖疫苗安全性监测.docVIP

社区老年人接种23价肺炎球菌多糖疫苗安全性监测 　　摘要：[目的] 监测2014-2015年上海市长宁区社区老年人群接种23价肺炎球菌多糖疫苗（PPV23）的安全性，为老年人肺炎链球菌性疾病免疫策略及政策延续提供依据。[方法] 通过“上海市老年人免费接种23价肺炎球菌多糖疫苗”项目的“安全性监测”研究，以主动监测与被动监测相结合的方式收集长宁区60岁及以上户籍老年人肺炎疫苗接种人群2014年1月-2015年7月的AEFI个案信息开展评价。 [结果] 上海市长宁区60岁及以上户籍老年人2014年1月-2015年7月共免费接种肺炎疫苗11556剂，肺炎疫苗AEFI被动监测报告发生率132.88/10万，均为一般反应；肺炎疫苗AEFI主动监测报告发生率196.08/10万，主动监测的AEFI?蟾娣⑸?率高于被动监测。肺炎疫苗AEFI报告对象的临床表现以局部红肿、低热、局部硬结为主，无异常反应，无严重不良反应发生。[结论] 老年人群接种肺炎疫苗是非常安全可靠的 关键词：23价肺炎球菌多糖疫苗；预防接种；安全性 中图分类号：R186 文献标识码：A 文章编号： Abstract： [Objective] To monitor the safety of PPV23 Vaccination from January 2014 to July 2015 in Changning District of Shanghai.To provide evidence for the immunization strategy and policy of the elderly people with Streptococcus pneumonia .[Methods] The data on adverse events following immunization （AEFI） were collected following the study through a passive surveillance system and an active surveillance among 60 years old and above the household registration elderly people.[Results] A total of 11556 PPV23 vaccine shots were administered freely during the study period in community elderly people in this district.The reported AEFI incidence through the passive surveillance system was 132.88 per 100000. They are all general reaction. The reported AEFI incidence through the active surveillance system was 196.08 per 100000，which was higher than that through the passive surveillance.The syndromes reported by AEFI were mainly local swelling， low-grade fever and local induration.No adverse event was reported.[Conclusion] PPV23 vaccination is very safe in community elderly people. Key Words： PPV23 Vaccine；Vaccination；Safety 据世界卫生组织估计，全球每年约有160万人继发死于肺炎球菌疾病，尤其是 　　4.2 被动监测 利用上海市预防接种异常反应（adverse events following immunization，AEFI）监测系统和国家免疫规划信息管理系统（Information management system of China immunization program）开展疫苗安全性被动监测。受种者、接种单位、医疗机构、疾病预防控制中心、疫苗生产企业和药品不良反应监测中心等发现AEFI后，均可向所在地的接种单位或疾控中心报告，数据均录入监测系统 5 统计学分析 所得数据用EPI data软件建立数据库，采用SPSS18.0统计分析软件进行统计分析。研究数据均采用双侧检验，AEFI报告发生率的比较采用泊松x2?z验，显著性