AHS淋巴瘤干细胞移植-培训课件.ppt

* * * * The Mantle Cell Lymphoma International Prognostic Index (MIPI) is superior to the International Prognostic Index (IPI) in predicting survival following intensive first-line immunochemotherapy and autologous stem cell transplantation (ASCT) * * * * * * PBSC的动员？？ 大剂量G-CSF 联合生长因子：G-CSF+ GM-CSF 长效G-CSF 新动员剂：mozobil 中山大学肿瘤医院 SUN YAT-SEN UNIVERSITY CANCER CENTER 自体移植，ASCT 适应症：淋巴瘤 1.敏感复发 DLBCL 2.初治高危 （aa IPI 3）弥漫 大B细胞 ， 3.首次常规化疗仅获PR1， DLBCL, 4. 敏感复发低度恶性， FL, 复发MALT 5. 套细胞淋巴瘤一线，二线？ 5 .复发霍奇金淋巴瘤 6. 外周T细胞，初治NK/T 晚期、复发难治 7. 其 他 ： 初治LBL？ 展望：如何提高ASCT疗效 移植前尽量降低肿瘤负荷，PET/CT Tandem 移植，双移植（auto-auto; auto-allo ） 新药治疗 ， thalidomide？ PD-1单抗 长效干扰素 其他 中山大学肿瘤医院 SUN YAT-SEN UNIVERSITY CANCER CENTER 移植病房启用20年纪念 中山大学肿瘤医院 SUN YAT-SEN UNIVERSITY CANCER CENTER THANK YOU！ 中山大学肿瘤防治中心 * * * * * * * * * * * * * Intensive Chemotherapy Followed by Hematopoietic Stem-Cell Rescue for Refractory and Recurrent Primary CNS and Intraocular Lymphoma: Société Fran?aise de Greffe de Mo?lle Osseuse-Thérapie Cellulaire Carole Soussain, /content/26/15/2512.long * HIGH-DOSE CHEMOTHERAPY WITH AUTOLOGOUS STEM CELL TRANSPLANTATION FOR ELDERLY PATIENTS WITH RELAPSED/ REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA: A RETROSPECTIVE ANALYSIS FROM THE ADULT LYMPHOMA WORKING GROUP OF THE JAPAN SOCIETY FOR HEMATOPOIETIC CELL TRANSPLANTATION * * * * * EFS, event-free survival; FL, follicular lymphoma; PFS, progression-free survival. ? Another option would be to consolidate patients with upfront hematopoietic stem cell transplantation. At least 4 prospective, randomized trials including studies from the French, German, and Italian Cooperative Groups have examined this approach. As shown on this slide, all of the trials showed improvements in progression-free survival or event-free survival with hematopoietic stem cell transplantation relative to controls. For example, the Italian trial showed an improvement in the 4-year event-free survival from 28%