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Cancer Chemother Pharmacol (2011) 67:1027–1034
DOI 10.1007/s00280-010-1399-5
ORIGINAL ARTICLE
Induction chemotherapy with carboplatin and taxol followed
by radiotherapy and concurrent weekly carboplatin + taxol
in locally advanced nasopharyngeal carcinoma
Mario Airoldi • Pietro Gabriele • Anna Maria Gabriele •
Massimiliano Garzaro • Luca Raimondo • Fulvia Pedani •
Fabio Beatrice • Giancarlo Pecorari • Carlo Giordano
Received: 10 April 2010 / Accepted: 6 July 2010 / Published online: 20 July 2010
Springer-Verlag 2010
Abstract Conclusions Neoadjuvant chemotherapy with such pro-
Purpose Aim of this study was the clinical evaluation of tocol represents a feasible, efficient treatment for patients
carboplatin–taxol combination in a neoadjuvant and con- with A-NPC, ensuring excellent loco-regional disease
comitant setting with conventional radiotherapy in loco- control and overall survival with low incidence of distant
regionally advanced nasopharyngeal carcinoma (A-NPC). metastases.
Methods Thirty patients were treated with three cycles of
carboplatin (AUC6) plus taxol (175 mg/m2) on day 1 every Keywords Nasopharyngeal carcinoma
3 weeks, followed by weekly carboplatin (AUC1) plus Neoadjuvant chemotherapy Chemoradiation
Taxol (60 mg/m2) and concomitant radiotherapy (70 Gy). Carboplatin Taxol
Results We observed the objective complete response
rates of 33% (after chemotherapy) and 87% (after chemo-
radiotherapy). Treatment tolerability and toxicity were Introduction
controllable. Three- and five-year progression-free survival
were 80 and 75%, respectively, and 3- and 5-year overall In nasopharyngeal carcinoma (NPC), the place of chemo-
survival were 85 and 80% (foll
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