Hyper-CVAD医.pdfVIP

CODE: Hyper-CVAD A REGIMEN NAME Hyper-CVAD Chemotherapy Cancer Non-Hodgkin’s Lymphoma (High Grade) Curative Lymphoblastic Lymphoma Regimen Core: Standard therapy endorsed by the Disease Site Group and a regimen Category widely used by most Integrated Cancer Progra ms in this disease site B DRUG REGIMEN Course A: CYCLOPHOSPHAMIDE 300mg/m2 IV over 3 hours Q12H x 6 doses Days 1, 2, and 3 MESNA may be given as an uroprotectant at the same total dose as cyclophosphamide but given by continuous infusion starti ng with cyclophosphamide and ending 6 hours after the last dose. (Although Mesna is recommended in the cited reference (Kantarjian et al.), most RCC’s usually do not administer Mesna with this dose of Cyclophosphamide.) METHOTREXATE 12mg IT Day 2 DOXORUBICIN 50mg/ m2 IV Day 4 VINCRISTINE 2mg IV Days 4 and 11 DEXAMETHASONE 40mg/day IV or PO Days 1 to 4 Days 11-14 CYTARABINE 70mg IT Day 7 Course B: METHOTREXATE 1000mg/ m2 IV over 24 hours Day 1 LEUCOVORIN 25mg/ m2 IV 24 hours after Q6H X 6 doses starting Methotrexate infusion Sodium Bicarbonate 600mg PO (starting day TID X 4 Days