阻塞性睡眠呼吸暂停低通气综合征对脑梗死患者认知功能.PDFVIP

浙江医学浙江医年第年第3939 卷第卷第86 期期 阻塞性睡眠呼吸暂停低通气 综合征对脑梗死患者认知功能 的影响 张昀赟 陈季志 牛艳芳 查芹 翁秋燕 王美华 【摘要 】 目的 分析脑梗死合并阻塞性睡眠呼吸暂停综合征（OSAS ）患者认知功能的特点，探讨OSAS 对此类患者的影响。 方法 选择2014 年3 月至2016 年9 月住院治疗的脑梗死急性期患者148 例。依据多导睡眠图（PSG ）监测，分为单纯脑梗死组98 例 和脑梗死合并OSAS 组50 例。两组患者分别行蒙特利尔认知评估（MoCA ）量表测定和事件相关电位（ERP ）P300 检测，比较两组患者 MoCA 总分以及各认知域的分数和P300 潜伏期、波幅的测定结果。 结果 脑梗死合并OSAS 组患者视空间与执行功能、命名能力、 延迟记忆、注意力、语言、抽象、定向力得分与总分均低于单纯脑梗死组，差异均有统计学意义（P＜0.05 ）。脑梗死合并OSAS 组患者 P300 潜伏期较单纯脑梗死组患者延长，波幅较单纯脑梗死组患者降低，差异均有统计学意义（均P＜0.05 ）。结论 OSAS 可加重脑 梗死患者认知功能障碍。 【关键词】 阻塞性睡眠呼吸暂停综合征 脑梗死 认知功能障碍 MoCA 量表 事件相关电位 Effect of obstructive sleep apnea syndrome on cognition in patients with cerebral infarction om zzs.c China 【Abstract 】 Objective To investigate the effect of obstructive sleep apnea syndrome (OSAS) on cognition in patients with .zjyx cerebral infarction. Methods One hundred and forty eight patients with acute cerebral infarction admitted in our hospital from www March 2014 to September 2016 were enrolled in the study. According to the results of polysomnography (PSG) monitoring, there 学》 were 50 cerebral infarction patients with OSAS (OSAS group) and 98 cases without OSAS (non-OSAS group). Results BMI and 浙江医 the proportion of male were higher in OSAS group than those in non-OSAS group (P ＜0.05). The overall scores and scores of 《 sub-items in OSAS group were lower than those in non-OSAS group (P ＜0.05). There were significant differences in scores of visual space and executive function, memory, attention, language and abstraction between two groups (P ＜0.01). The latency of P300 in OSAS group was prolonged and the amplitude was decreased (P ＜0.01 or P ＜0.05). Concl