Biofilm 细菌生物膜的 适用医学生.ppt

细菌生物膜;“In a paper in Science in 1999, we said 65 percent of all diseases in the developed world are biofilms,” Costerton said. “Now the NIH says 80 percent. ”;on a contact lens;细菌生物膜广泛存在于自然环境中 Biofilm formation appears early in the fossil record (3.25 billion years ago) and is common throughout a diverse range of organisms in both the Archaea/ 单细胞生物 and Bacteria lineages. Biofilm formation represents a protected mode of growth that allows cells to survive in hostile environments and also disperse to colonize new niches.;回肠表面的细菌生物被膜;人体植入导管表面的细菌生物被膜;真菌生物膜;Biofilms can be harmful Catheters and prostheses (may lead to systemic infection) Dental disease （牙菌斑、口腔味道？） Otitis media/中耳炎, inflammatory bowel disease/IBD, prostatitis/前列腺炎, sinusitis/鼻窦炎, etc. ;生物膜与疾病（总结）;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd.;细菌生物膜进入体内的可能途径;细菌生物膜的基本性质;Biofilms — matrix-enclosed microbial accretions/逐渐生长/增加 that adhere to biological or non-biological surfaces. 古老：fossil record (3.25 billion years ago) Common：a diverse range of organisms Archaea/ 单细胞生物, bacteria，fungi Represents a protected mode of growth that allows cells to survive in hostile environments Can disperse to colonize new niches/ 可以释放出浮游细菌，生长迅速，是潜在感染因素;Biofilm 的形成过程- 体内过程;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd.;Biofilm 的形成过程- 从菌落角度;;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd.;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd.;Nature Rev Micro 2010;Evaluation only. Created with Aspose.Slides for .NET 3.5 Client Profile . Copyright 2004-2011 Aspose Pty Ltd.;化学组成 ? 水分（97%） ? 胞外大分子 ? 吸附的营养物质及代谢产物、细菌裂解物 ? 蛋白质、DNA ;生物膜的结构特点 成熟生物被膜模型 ? 由外到内依次为： 生物被膜层（bulk of biofilm） 连接层（linking film） 条件层（conditioning film）