第二十三章 速效救心丸对急性冠脉综合征患者早期.doc

速效救心丸对急性冠脉综合征患者早期 经皮冠状动脉介入效果的影响 王 摘要 目的 探讨速效救心丸对急性冠脉综合征（cute coronary syndrome, ACS）患者早期, PCI）效果的影响。方法 60ACS患者随机分为速效救心丸治疗组（治疗组）和西药对照组（对照组），动脉造影检查，并行早期PCI，速效救心丸干预对ACS患者支架植入后冠脉血流血侧枝开放以及围手术期心梗发生率的影响。 结果 PCI术前还是术后，治疗组冠脉血流术前TIMI）血流分级达到3级：16 vs 11/30，p0.01；术TIMI血流vs 13/19，p0.05）；TIMI血流~1级治疗组侧支（vs 3/13，p0.05）；治疗组围术期（vs 15/30，p0.05）。结论 速效救心丸改善ACS患者支架植入后冠脉血流减少围手术期的发生率。 关键词 急性冠脉综合征；冠状动脉造影；侧枝；围手术期Effects of Suxiao Jiuxin Pill on Patients with Acute Coronary Syndrome Undergoing Early Percutaneous Coronary Intervention WANG Xiao-long，LIU Yong-ming，ZHU Gu-jing，et al Department of Cardiology，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai ( 201203) ABSTRACT Objective To investigate the intervention effects of Suxiao Jiuxin Pill ( SJP) on patients with acute Coronary syndrome (ACS) undergoing early percutaneous coronary intervention ( PCI) ．Methods Sixty ACS patients were randomly assigned to the treatment group ( treated by SJP and Western medicine) and the control group ( treated by Western medicine alone) ，30 in each group．Coronary arteriography and early PCI were performed in all patients. The effects of SJP on the blood flow rate，the collateral artery patency，and perioperative myocardial infarction incidence were observed． Results The coronary blood flow rate was better in the treatment group than in the control group either pre- or post-PCI．［pre-PCI thrombolysis in myocardial infarction( TIMI) level Ⅲ: 16 /30 vs 11 /30，P ＜ 0. 01; post-PCI TIMI level Ⅲ: 14 /14 vs 13 /19，P ＜ 0. 05) ］．In patients with ITMI level 0 －Ⅰ，more patients in the treatment group had collateral artery protective function than those in the control group ( 5 /6 vs 3 /13，P ＜ 0. 05) ．The incidence of perioperative myocardial infarction was obviously lower in the treatment group than in the control group ( 8 /30 vs 15 /30，P ＜ 0. 05) ．Conclusion SJP could improve the pre- and post-PCI coronary artery flow rate，increase the collateral artery patency，and reduce