免疫球蛋白与MHC.ppt

Complementarty Interactions between Proteins Ligands: lmmune Systemand lmmunoglobulins 汇报人：许阳春 MHC分子 IgG CONTENT MHC’s structure MHC’s functions questions The process of immune response  Structure of a class I MHC molecules. Schematic diagram illustrates the different regions of MHC molecules. Class I molecules are composed of a ? chain noncovalently attached to the ?2-micorglobulin.Schematic diagram Showing the peptide-binding cleft consisting of a base of antiparallel ? strands and sides of ? helices. This cleft in Class I molecules can accommodate peptides containing 8-10 residues. The ?3 segment of the ? chain folds into an Ig domain that serves as the binding site for CD8. ? Structure of a class I I MHC molecules.  Schematic diagram illustrates the different regions of MHC molecules. Class iI molecules are composed of a ? chain noncovalently attached to the ? chain. The peptide-biding region ? 1+ ? 1. ?2 segment binds the CD4 molecules expressed on helper T cells Peptide-binding cleft ? 1- domain ? 2- domain b2-microglubuin ? 3 domain ClassI ClassII Immune System Humoral Immune System Cellular Immune System heart lmmunoglobulins B cells produce Bind bacteria viruses or large molecules identified as foreign and target them for distruction heart T cells Helper T cells Cytokines Infected cells MHC produce stimulate T cell receptor surface surface Peptide fragment combine cells lysates 1、 Antigen presentation 2、The MHC restrictive of T cells 3、 Immune regulation Genetic control of immune response 4、 The differentiation of T cells 5、 Graft rejection 6、 受 QUESTIONS 1.为什么器官移植时，寻找合适的供体如此困难？ 3.MHC分子在特异性免疫应答中的重要作用？ 2.细胞表面分子MHC参与的免疫应答过程是？ CONTENT Immunoglobulin G’s structure Immunoglobulin’s functions questions Immunoglobulin G (IgG) is the major class of anti-body moleculea nd one of the most abundantp roteins inthe blood serurn. IgG has four polypeptide chains : two large ones, called heavy chains, and two lig