肺再灌注损伤Lung Reperfusion Injury After Transplantation课件.pptVIP

Gene Therapy Transfection of the donor lung through transtracheal route using a 2nd-generation adenoviral vector Transfection of the gene coding for anti-inflammatory cytokine, human IL-10, reduced ischemia-reperfusion injury, improves lung function in a rat single lung transplant model Human lung protection by gene therapy may soon be possible Take Home Message Donor lung assessment Effect of cold ischemic storage Oxidative stress Sodium pump inactivation Intracellular calcium overload Iron release Cell death Consequences of ischemia reperfusion Up-regulation of molecules on cell surface mem