双芍护睛散抗大鼠外伤性视神经损伤的视网膜神经纤维层观察.pdfVIP

Hans Journal of Ophthalmology 眼科学, 2017, 6(1), 30-34 Published Online March 2017 in Hans. /journal/hjo /10.12677/hjo.2017.61006 Observation of Retinal Nerve Fiber Layer in Rats with Traumatic Optic Nerve Injury Treated by Shuang Shao Hu Jing powder * Jiaxiang Xiao , Ting Wen, Ying Yao Ophthalmology of Guizhou Province Hospital of Traditional Chinese Medicine, Guiyang Guizhou th th st Received: Mar. 16 , 2017; accepted: Mar. 27 , 2017; published: Mar. 31 , 2017 Abstract Objective: To observe the change of retinal nerve fiber layer of rats with traumatic optic nerve ınjury that treated by Shuang Shao Hu Jing Powder. Methods: 15 rats were randomly se- lected from 60 SD rats as control group, and the remaining 45 model rats were randomly divided into model control group, saline group and TCM treatment group; each group had 15 rats. Retina of the blank control group and the model control group were peeled after 24 hours, while that of the normal saline group and TCM treatment group (Shuang shao hu jing powder) were peeled after 4 weeks of treatment. Changes of retinal ganglion cells and nerve fiber layer morphology and thick- ness were observed. Results: In the model control group, there was a large amount of RGC in the re- tina, and the nerve fiber layer was significantly thickened. The thickness of the nerve fiber layer was significantly different from that of the control group (P 0.05). A large number of RGC in the normal saline group showed vacuolar degeneration, shedding, and the nerve fiber layer became thinner; while in the treatment group, there was a slight swelling of RGC in the retina and a slight thinning of the nerve fiber layer, and there was significant difference betwee