炎症介质与抗炎药物.pptx

炎症介质与抗炎药物Inflammatory mediators and anti-inflammatory drugs;Inflammation (炎症）;The Process of Inflammation;Why do we need anti-inflammatory drugs? ;THE INFLAMMATORY PROCESS;The phases of inflammatory responses;Inflammatory Mediators;Eicosanoids 类花生酸;Arachidonate Metabolism Pathways;Cyclooxygenase (COX);15-Prostaglandin Dehydrogenase;COX-2 and 15-PGDH ;NONSTEROIDAL ANTIINFLAMMATORYDRUGS (NSAIDs);Mechanism of Action;Adverse Effects of NSAIDs;Biological Oxidants;Cytokines;Approximately one million individuals worldwide are either undergoing treatment or have been treated with TNF inhibitors available in the pharmaceutical market, encompassing indications that include rheumatoid arthritis, psoriatic arthritis牛皮癣性关节炎, psoriasis银屑病and inflammatory bowel diseases炎症性肠病;糖皮质激素（Glucocorticoid），又名“肾上腺皮质激素”，是由肾上腺皮质分泌的一类甾体激素;The potential consequences of systemic administration of the corticosteroids include adrenal suppression, cushingoid changes, growth retardation, cataracts, osteoporosis, CNS effects and behavioral disturbances, and increased susceptibility to infection.;Aerosol corticosteroids asthma therapy