结缔组织病相关肺间质病变临床特点分析.docVIP

结缔组织病相关肺间质病变临床特点分析 　　DOI：10.16662/j.cnki.1674-0742.2017.07.068 [摘要] 目的 探讨结缔组织病相关的肺间质病变的临床特点。方法 回顾性分析该院呼吸内科于2010年6月―2015年6月期间确诊的结缔组织病合并肺间质病变患者20例，分析临床特点、实验室检查及影像学表现。结果 20例患者均以肺部病变为首发、主要表现，多以干咳和隐匿性呼吸困难起病，入院诊断为肺部感染、间质性肺炎10例，误诊率50.00%；自身抗体阳性12例，占60.00%，多器官系统受累14例，占70.00%。结论 起病初期，结缔组织病有关肺间质病变表现不明显，误诊率较高，尽早行HRCT扫描，结合结缔组织病有关的肺间质病变的临床特点有利于早期诊断，及时治疗干预改善病情 [关键词] 结缔组织病；肺间质病变；临床特点；分析 [中图分类号] R593.2 [文献标识码] A [文章编号] 1674-0742（2017）03（a）-0068-03 Analysis of Clinical Features of Connective Tissue Disorder Related Interstitial Lung Disease ZHOU Ming-yuan Department of Respiration Medicine， Chuxiong Peoples Hospital， Chuxiong， Yunnan Province， 657000 China [Abstract] Objective To discuss the clinical features of connective tissue disorder related interstitial lung disease. Methods 20 cases of patients with connective tissue disorder related interstitial lung disease diagnosed in our hospital from June 2010 to June 2015 were selected and the clinical features， laboratory examination and imaging performance were analyzed. Results The primary manifestation of all 20 patients was lung disease， onset of dry cough and latent dyspnea， and the admission diagnosis showed that there were 10 cases with lung infection and interstitial pneumonia， and the misdiagnosis rate was 50.00%， and there were 12 cases with positive autoantibody， accounting for 60.00% and 14 cases with multi- organ system involvement， accounting for 70.00%. Conclusion The manifestation of connective tissue disorder related interstitial lung disease is not obvious during the early stage with higher misdiagnosis rate， and conducting the HRCT scan early combined with the clinical features of connective tissue disorder related interstitial lung disease is conducive to the early diagnosis and treatment of disease in time. [Key words] Connective tissue disorder； Interstitial lung disease； Clinical feature； Analysis ?Y缔组织病（即CTD）造成人体肺损害类型主要包括肺间质发生病变（即ILD）、细支气管炎以及肺部动脉高压等，在这之中ILD是最为常见且可能对患者的预后产生最大影响的病变类型[1]。