amyloid抗细胞增殖文章.pdf

Article Adaptation to Stressors by Systemic Protein Amyloidogenesis Graphical Abstract Authors Timothy E. Audas, Danielle E. Audas, Mathieu D. Jacob, ..., Laura Trinkle-Mulcahy, Mark L. Gonzalgo, Stephen Lee Correspondence stephenlee@ In Brief Audas et al. find that to adapt to stressors, heterogeneous proteins convert to an amyloid-like state and form subnuclear amyloid bodies (A-bodies), which requires a specific protein motif and ribosomal intergenic lncRNA. Upon stimuli termination, Hsp chaperones disaggregate A-bodies. This pathway regulates reversible amyloidogenesis of the Alzheimer’s disease-associ