药理学讲义02 Drug Action.ppt

Chapter 1 Targets of Drug Action 靶点 Targets of Drug Action 1. RECEPTORS 受体 Types of receptors 1.2. Receptors Linked to G-Proteins G蛋白 1.2.1. G-Protein Coupled to an Enzyme 酶 Second-Messengers (第二信使) and Actions of G-Proteins Coupled to Enzymes 1.2.2. G-Protein Coupled toan Ion Channel 离子通道 The Na/K Pump 泵 Ion Channels 离子通道 1.3. Receptors Directly Linkedto Enzymes 酶 1.4. Receptors Directly Linked to Ion Channels 离子通道 (Ionotropic Receptors) 1.5. Receptors Directly Linkedto Gene Transcription 调节基因表达 2. CARRIERS 主动扩散 The Proton Pump 泵 in the Stomach 胃 The monoamine reuptake 一元胺回收 3. ION CHANNELS 离子通道 4. ENZYMES 酶 Antidepressant drugs inhibit the reuptake of noradrenaline and 5-HT * * Some drugs have a purely chemical action. Ex, antacids Most drugs act on a TARGET 靶点 protein receptors carriers ion channels enzymes DRUG TARGETS 酶 4. ENZYMES 离子通道 3. CHANNELS 主动扩散 2. CARRIERS 调节基因表达的受体 1.5. directly linked to gene transcription 离子通道的受体 1.4. directly linked to ion channels 酶的受体 1.3. directly linked to enzymes 离子通道的G蛋白 1.2.2. G-protein coupled to an ion channel 酶的G蛋白 1.2.1. G-protein coupled to an enzyme G蛋白偶联受体 1.2. linked to G-proteins 受体 1. RECEPTORS Receptors are protein molecules in or on cells that interact with endogenous messenger molecules –hormones, neuro-transmitters,… – to coordinate the activities of cells in the body Agonists: albuterol, isoetharine, terbutaline; Antagonist: propranolol Dilation of smooth muscle in blood vessels, airways, digestive tract, and urinary tract; breakdown of glycogen in skeletal muscles (releasing glucose for energy) Adrenaline and noradrenaline Adrenergic Beta 2 Agonists: dobutamine and isoproterenol; Antagonists: beta-blockers, such as atenolol, metoprolol Increase in heart rate, in the force of heart contraction, and in secretion of renin (a hormone involved in the control of blood pressure) Adrenaline and noradrenaline Adrenergic Beta 1 Agonist: clonidine Antagonist: yohimbine Decrease in insulin secretio