重叠综合症研究.ppt

材料来源 Main teaching points 引言 ACOS Phenotype of COPD ? Prevalence of ACOS Different criteria different outcome Burden of ACOS Fattahi F. Atopy is a risk factor for respiratory symptoms in COPD patients: results from the EUROSCOP study.Respir. Res. 2013; 14: 10. PATHOPHYSIOLOGY OF ACOS 基因GENE 病理和气道功能STRUCTURAL CHANGES 临床表现MANIFESTATION Gene Th2 inflamation Step-wise approach to diagnosing ACOS Asthma ACOS childhood asthma with persistent wheeze from the first years of life into adulthood Longstanding asthma without taking ICS adult-onset asthma severe or difficult-to-treat asthma COPD ACOS Avaliable features Recall bias Lack of lung function testing typical symptoms and respond to ICS GINA and GOLD. Diagnosis of diseases of chronic airflow limitation:asthma, COPD and asthma-COPD overlap syndrome(ACOS) (updated 2015). Available from URL: http:///. Accessed: 13 April 2015. Sputum Eosinophil Counts Management Individualized management ICS may be considered in patients with ACOS with significant sputum eosinophilia (eosinophil count ≥ 3%). Disability Future ACOS Studies First, which genes are the genetic risk factors for developing ACOS? the second question is what are the molecular pathways of ACOS? Third, what is the natural course or prognosis of ACOS? Conclusions ACOS may be an interim term applicable to patients in whom it is difficult to distinguish between asthma and COPD. An alternative approach to chronic obstructive airway disease is to describe rather than to categorize the disease. 滨州市人民医院 Binzhou Peoples Hospital 大医精诚 厚德至善 滨州市人民医院 Binzhou Peoples Hospital 大医精诚 厚德至善 滨州市人民医院 Binzhou Peoples Hospital 大医精诚 厚德至善 滨州市人民医院 Binzhou Peoples Hospital 大医精诚 厚德至善 滨州市人民医院 Binzhou Peoples Hospital 大医精诚 厚德至善 呼吸内科 朱建波 重叠综合征是同时具有哮喘和慢阻肺特点的气流受限性疾病 除了吸入激素和支气管扩张药物外，有必要明确和排除可避免的危险因素，比如吸烟。 肺功能快速下降的重叠综合征病人多见于哮喘合并吸烟的患者 asthma ACOS COPD Andersen H. High hospital burden in overlap syndrome of asthma and COPD. Clin. Resp