肠应激综合征治疗药物的进展与应用评价.pdfVIP

DOI :10.14009/j.issn.1672 -2124.2006.03.003 ·· 肠应激综合征治疗药物的进展与应用评价 杨学文, 张石革 (北京大学第四临床医学院北京积水潭医院, 北京市　100035 ) 　R975 　　　　A　　　　1672-2124(2006)03-0136-03 　　目的:评价肠易激综合征药物治疗的疗效、不良反应和药物经济学, 以供临床用药参考。 方 :通过查阅近期国内、外相 关文献总结、分析。 结果与结论:目前肠易激综合征尚无确切的治疗方 , 主要是对症治疗和综合治疗, 包括患者教育、心理疗 、 饮食调整等, 而药物治疗主要在于改善胃肠道动力, 解除肠管痉挛, 减轻肠管扩张以及抗菌消炎等, 并且尽可能实施 个体化治疗方 案。 　肠易激综合征;抗抑郁药物;5-HT 能药物;临床 ProgressandEvaluationoftheDrugs fortheTreatment ofIrritable Bowel Syndrome YANG Xuewen, ZHANG Shige (Beijing Jishuit n Hospit l, the Fourth Clinic l Medic l College of Peking University, Beijing 100035) ABSTRACT　OBJECTIVE:To ev lu te the effic cy, dverse re ctions nd ph rm coeconomics of the drugs for the tre tment of irrit ble bowel syndrome(IBS), in order to give some references for clinic l drug use.METHODS:By reviewing recent liter tures t home nd bro d for n n lysis nd summ ry.RESULTS CONCLUSION:Up to now, there is no confirm tive tre ting method for IBS, m inly re symptom tic tre tment nd combined ther py including p tientseduc tion, psychother py, diet djustment nd so on.Drug ther py is m inly for improving dyn mi of g strointestin l tr ct , relieving sp sm of intestin l c n l, reducing distension of intestin l c n l nd fighting g inst b cteri ls nd elimin ting infl mm tion. Individu l ther peutic pl n should be c rried out s f r s possible. KEY ORDS　irrit ble bowel syndrome;ntidepress nt drugs;5-HT energy drugs;clinic 　　(Irrit ble Bowel Syndrome, IBS) (-), , , , , , 、、 。 , , 、、 , IBS。 [1] , , 。 , 10%～ 20%, 8%～23%, 7.2%, , 、, , 。 75%。 , IBS , , 2 , ;, , 3 , 799 , 881, 89% 28%、29%33%, 58% , 1 2mg、6mg, 1 2 , 12 , 。 , 4 50% 1　5-4