Historical Timeline of Nuclear Medicine 核医学发展史.doc

Historical Timeline Important?Moments in the History of Nuclear Medicine 1896 Henri Becquerel discovered mysterious rays from uranium. 1897 Marie Curie named the mysterious rays radioactivity. 1901 Henri Alexandre Danlos and Eugene Bloch placed radium in contact with a tuberculous skin lesion. 1903 Alexander Graham Bell suggested placing sources containing radium in or near tumors. 1913 Frederick Proescher published the first study on the intravenous injection of radium for therapy of various diseases. 1914 Seil studied the appearance of radon and radium in excreta after an intravenous injection of radium. 1924 Georg de Hevesy, J.A. Christiansen and Sven Lomholt performed the first radiotracer (lead-210 and bismuth-210) studies in animals. 1925 Herrman Blumgart and Otto Yens used bismuth-214 (radium-C) to determine the arm-to-arm circulation time in patients. 1932 Ernest O. Lawrence and M. Stanley Livingston published the first article on the production of high speed light ions without the use of high voltages. It was a milestone in the production of usable quantities of radionuclides. 1935 O. Chieivitz and Georg de Hevesy administered phosphate labeled with phosphorus-32 to rats and demonstrated the renewal of the mineral constituents of bone. 1936 John H. Lawrence, the brother of Ernest, made the first clinical therapeutic application of an artificial radionuclide when he used phosphorus-32 to treat leukemia. 1936 Joseph Gilbert Hamilton and Robert Spencer Stone administered sodium-24 to a leukemia patient. 1937 John Livingood, Fred Fairbrother and Glenn Seaborg discovered iron-59. 1937 Joseph Gilbert Hamilton performed the first medical physiology studies of the dynamics of sodium transport in the body. 1937 Saul Hertz, Arthur Roberts and Robley Evans studied thyroid physiology using iodine-128 1938 John Livingood and Glenn Seaborg discovered iodine-131 and cobalt-60. 1938 Emilio Segre and Glenn Seaborg discovered technetium-99m. 1939 Joseph Gilbert Hamilton,