迷迭香酸对mpp 导致mes 23 5细胞损伤保护作用(国外英语资料).docVIP

迷迭香酸对mpp 导致mes 23 5细胞损伤保护作用(国外英语资料) Rosemary acid has a protective effect on MPP + causing mes 23.5 cell damage Source: / The author: du tingting, song ning hsien, jiang hong 【 abstract 】 objective to observe rosemary acid to 1? Methyl? 4? Phenylpyridine cation (MPP +) results in the protective effect of mes 23.5 cell damage. Methods four methyl azazole salt (MTT) detection method was used to observe the protective effect of the isostonic acid of different concentrations on the MPP + treated mes 23.5 cells. Results 10 to 9 ~ 10 to 6 molar of rosemary acid were non-toxic to mes 23.5 cells (f = 0.581, p 0.05). 200 mu mol/l MPP + can lower the cell survival rate (f = 44.863, p 0.01), and the application of 10 to 9 ~ 10-6 mol/l rosemary acid after incubation cells, can obviously improve the survival rate of cells (p 0.01). Conclusion rosemary acid can antagonize MPP + and has certain neuroprotective effect on the toxicity of mes 23.5 cells. [keywords] rosemary; 1? Methyl? 4? Phenyl pyridine. Mes 23.5 cells Abstract objective to investigate the neuroprotective effect of rosmarinic acid on 1? Methyl? 4? Phenylpyridinium (MPP +)? Induced damage of mes cells. 23.5 the methods determined by MTT assay was 2 observe the protection of rosmarinic acid, in the company concentrations, on MPP +? Did not produce any to? Xic effect on mes 23.5 cells (f = 0.581, p 0.05). The cell viability decreased when treated with 200 mu mol/l MPP + (f = 44.863, p 0.01) by pretreatment with the 10-9-10-6 mol/l rosmarinic acid significantly elevated the cell survival rate (p 0.01). Conclusion rosmarinic acid can antagonize the toxic action of MPP + 23.5 cells on mes, possessing a certain neuroprotective effect. Key words rosmarinic acid; 1? Methyl? 4? Phenylpyridinium; Mes 23.5 cells Parkinsons disease (pd) is the second most neurodegenerative disease in the nervous system after alzheimers disease. The pds main pathology changes are the depletion of the black dense dopamine-dopaminergic (da) neuron