广西原发性肝癌高危人群茶多酚干预研究.pdf

2010年第37 卷第12期 中国肿瘤临床 707 广西原发性肝癌高危人群的茶多酚干预研究 ① ② 唐耘天 黄天壬 王加生 评估茶多酚对广西原发性肝癌高危人群在黄曲霉毒素暴露中的预防效果。 本研究采用随机双盲法进行 摘要 目的： 方法： 为期1年的茶多酚干预性试验，共有130例经过筛选的实验对象，严格按照随机双盲法分为两组：茶多酚组和安慰剂组；各组分别 服用茶多酚500mg/d 和相应的安慰剂；并在多个时间点采集血液样品，利用放射免疫法检测不同时间点两组实验对象血清中的黄 曲霉毒素白蛋白加合物水平。 130例实验对象的血清中均可检测到黄曲霉毒素白蛋白加合物。两组中茶多酚干预组实验 结果： 对象血清的黄曲霉毒素白蛋白加合物水平呈下降趋势，并在服用茶多酚12 个月后呈现显著性降低的情况（P0.05 ）；而安慰剂组 实验对象血清各时间点的黄曲霉毒素白蛋白加合物水平未出现显著性的改变（P0.05 ）。 茶多酚可以降低原发性肝癌高发 结论： 人群黄曲霉毒素的暴露水平。 关键词 茶多酚 黄曲霉毒素 原发性肝癌 doi:10.3969/j.issn. 1000-8179.2010.12.013 AStudyoftheInterventionofTeaPolyphenolsinaPopulationatHigh-riskofLiverCancer 1 2 TANG Yuntian, HUANG Tianren , WANG Jiasheng Corresponding author: TANG Yuntian, E-mail: TYTSHL2000@Y Department of Hepatobiliary Surgery, Peoples Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China 1Guangxi Tumor Hospital, Nanning 530021, China 2TIEHH, Texas Tech University, Lubbock 79409, U.S.A. Abstract Objective:To investigate the chemopreventive effects of tea polyphenols in high-risk individuals of liver can- cer. Methods: In this one-year study, 130 high-risk individuals were assigned into 2 groups by randomized and double blind principle; the tea polyphenols group (500mg tea polyphenols) and the placebo group. The phenotypic biomarker, AFB1-al- bumin adducts, was measured in serum samples, and collected at different time-points by RIA. Results:All serum samples were detectable in the 2 groups. In the tea polyphenols group, compared to baseline, a significant decrease of AFB1-albu- min adducts was found 12 months after interventi