2014-Mycoses-口头发言.pdfVIP

mycoses Diagnosis,Therapy and Prophylaxis of Fungal Diseases Abstract Oral Abstracts Keynote 3 Hitch hiking through the blood–brain barrier Keynote 1 1 2 3 2 Y. Jong, Y. C. Chang, E. Tseng and K. J. Kwon-Chung 1Children’s Hospital Los Angeles, USC Keck School of Medicine, Cryptococcal meningitis – the ongoing challenge Los Angeles, CA, USA; 2NIAID, Bethesda, MD, USA and 3Mackay T. S. Harrison Medical College, Taipei, Taiwan St Georges University of London, London, UK Background Pathogenic yeast Cryptococcus neoformans (Cn) can dis- In a landmark 2009 study, the CDC estimated that globally crypto- seminate through the blood stream, enter the brain, and cause dev- coccosis was associated with around 600 000 deaths per year, dri- astating meningoencephalitis. In order to cause brain infection, Cn ven in very large part by HIV-related cases in Sub-Saharan Africa. must penetrate through the blood–brain barrier (BBB). The BBB is The confidence intervals for this estimate were wide and the point the boundary between the brain parenchyma and blood circulation, estimate may now be on the