AD以及行为学.ppt

无明显变化 behavior tests----水迷宫实验（morris water maze） SAM小鼠确实表现出包括外在衰老体征、情绪以及学习记忆能力方面的增龄性快速衰老现象。其作为一种自然衰老模型的合理性与可行性，可作为衰老模型、老年性痴呆模型或是情绪行为紊乱模型，在衰老和老年性痴呆机制研究、药物筛选等方面及抗精神药物研究等方面均具有很好的应用前景。 summary AD以及行为学 AD 水迷宫、高架十字迷宫、筑巢行为等 Foreword 麻砚涛 112611006 2010.7.27 Outline 阿尔茨海默症(Alzheimer disease，AD)是发生在老年期或老年前期的一种中枢神经系统退行性疾病，以神经细胞内神经纤维缠结(nervefiber tangles，NFT)和细胞外老年斑(senile plaques，SP)以及大量神经元丢失为主要神经病理特征。 临床表现 1、进行性精神状态衰变； 2、记忆、智力、定向、判断能力、情感障碍和行为失常甚至发生意识模糊等； 3、患者通常在发病后5～6年内死于继发感染和全身衰竭。 Background Alois Alzheimer （1864-1915） Identified the first published case of Alzheimers disease. Auguste Deter （1850-1906） The first person diagnosed with Alzheimers disease Background By 2006, there were 26.6 million sufferers worldwide. Alzheimers is predicted to affect 1 in 85 people globally by 2050. Background  A brain without the disease A brain with advanced Alzheimers disease Background 病理特征 1、神经纤维缠结 2、淀粉样蛋白斑 Background Noticeable problems coming up with the right word or name Trouble remembering names Increasing trouble with planning or organizing stage 1 stage 2 stage 3 stage 4 stage 5 stage 6 stage 7 No impairment (normal function) Very mild cognitive decline (may feel as if he or she is having memory lapses) Mild cognitive decline Moderate cognitive decline/Mild or early-stage Alzheimers disease Background Forgetfulness of recent events/ones own personal history Greater difficulty performing complex tasks Forgetfulness about Becoming moody or withdrawn Moderately severe cognitive decline Severe cognitive decline Severe or late-stage Alzheimers disease Unable to take care of oneself Severe Alzheimers? - may last from 1 - 5 years. Plaques and tangles (shown in the blue-shaded areas) tend to spread through the cortex in a predictable pattern as Alzheimers disease progresses. Earliest Alzheimers?- changes may begin 20 years or more before diagnosis. Mild to moderate Alzheimer stages?- generally last from