艾滋病初治患者国产抗病毒药物治疗52周疗效评价.pdfVIP

· 2O34· · 论著 · 艾滋病初治患者国产抗病毒药物治疗52周疗效评价 黄琴，孙洪清，胡越凯，张云智，齐唐凯，蒋卫民，潘孝彰，卢洪洲 【摘要】 目的 观察国产抗病毒药物治疗艾滋病初治患者的治疗效果，为国产抗病毒药物的推广提供理论依 据。方法 选择艾滋病初治患者20例，给予口服奈韦拉平联合2种不同核苷类药物治疗52周，于治疗前及治疗52周 分别检狲患者的血浆HIV—RNA病毒载量和血CD4+T淋巴细胞数等。结果 20例患者治疗前血cI)4T淋巴细胞计数为 (206．50±82．37)+／mm ，治疗52周时血CD 淋巴细胞计数为 (314．80±149．73)+／mm ，两者间差异有统计学意 义 (t=2．83，P0．05)；20例患者治疗前血浆HIV—RNA病毒载量为 (50467．05±46903 89)copies／ml，除1例患 者治疗后期病毒裁量反弹外，其他19例患者治疗52周时血浆HIV—RNA病毒载量均50 00 copies／ml，两者间差异有 统计学意义 (P0．05)。结论 国产抗病毒药物可使艾滋初治患者的血CD T淋巴细胞数升高，血浆HIV—RNA病毒 裁量下降。 【关键词】 艾滋病病毒；病毒裁量；CD4淋巴细胞计数；高效抗逆转录病毒治疗 【中图分类号】R 512 91 【文献标识码】A 【文章编号】1007—9572(2007)24—2034—02 Primary Evaluation on the Efficacy of Combined Therapy with Nevirapine plus Two Different N Ⅱs in AIDS NaiIre Pa- tlents for 52 WeeKs HUANG Qin，SUN Hong—qing，HU Yue—kai，et al,Infectious Department ofShanghai Public Health Clinical Cente Affiliated to Fudan University．Shanghai 201508． ina 【Abstract] Objective To observe the efficacy of combined therapy with Nevirapine plus two different NRlⅡs in 20 AIDS—naive patients．In order to offer the experience of drugs made in China．Methods 20 AIDS—naive patients have regime with Nevirapine plus two different N Ⅱs comb ined therapy for 52 weeks All cases were f0uowed up，the plasma HIV一1 RNA level and CD 4T cell counts of the patients were detected at be nning of treatment and the 52th week Results The CD 4T cell counts of the patients were(206、50±82 37)／mm3 at beginning of treatment，after 52 weeks，the CD 4T cell counts were (314 80±149 73)／mm 。comparison of the CD 4T cell counts between the prior and the post antiretroviral，they had statistical significant( =2．83，P0．05)；the HIV viral load of20 cases in prior treatment were(50467．05±46903．89) copies／ml。after treatment 52 weeks。the nineteen patients had not be detected in the blood(50．00 copies／ml，they had sta— fisfical significant(P0．05