替吉奥联合多西他赛化疗治疗进展期胃癌疗效及安全性.docVIP

替吉奥联合多西他赛化疗治疗进展期胃癌疗效及安全性 　　DOI：10.16662/j.cnki.1674-0742.2017.11.127 [摘要] 目的 探讨替吉奥联合多西他赛新辅助化疗治疗进展期胃癌的临床疗效及安全性。方法 便利选取该院2015年11月―2016年11月收治的进展期胃癌患者46例作为研究对象，均给予多西他赛联合替吉奥治疗，化疗2个周期后评估疗效，并记录患者不良反应发生情况。结果 完全缓解1例（2.17%），部分缓解34例（73.91%），稳定9例（19.57%），进展2例（4.35%），客观有效率为76.09%（35/46）。46例患者中，44例接受手术治疗，手术根治切除率86.36%（38/44），其中86.84%（33/38）患者接受D2淋巴结清扫术治疗，R0切除率为86.36%（38/44），无手术死亡病例。患者不良反应主要包括恶心、呕吐、中性粒细胞减少。结论 给予进展期胃癌患者替吉奥联合多西他赛治疗，疗效确切，不良反应耐受，值得临床进一步推广 [关键词] 替吉奥；胃癌；多西他赛；新辅助化疗 [中图分类号] R5 [文献标识码] A [文章?号] 1674-0742（2017）04（b）-0127-03 Curative Effect and Safety of S-1 and Docetaxel Chemotherapy in Treatment of Advanced Gastric Cancer FENG Jie-lin1，3，SHENG Li-jun2，3 1.Electrocardiographic Room， Affiliated Hospital of Shandong Academy of Medical Sciences， Jinan， Shandong Province， 250031 China；2.Department of Medical Oncology， Affiliated Hospital of Shandong Academy of Medical Sciences， Jinan， Shandong Province， 250031 China；3.School of Medicine and Life Sciences， Shandong Academy of Medical Sciences of University of Jinan， Jinan， Shandong Province， 250022 China [Abstract] Objective To discuss the clinical curative effect and safety of S-1 and docetaxel chemotherapy in treatment of advanced gastric cancer. Methods 46 cases of patients with advanced gastric cancer admitted and treated in our hospital from November 2015 to November 2016 were convenient selected and treated with S-1 and docetaxel， the curative effect was evaluated after 2-week chemotherapy and the occurrence of adverse reactions of patients was recorded. Results 1 case was totally relieved， accounting for 2.17%， 34 cases were partially relieved， accounting for 73.91%， 9 cases were steady， accounting for 19.57% and 2 cases were progressed， accounting for 4.35%， and the objective effective rate was 76.09%（35/46）， and of the 46 cases of patients， 44 cases accepted the operative treatment， and the radial incision rate of operation was 86.36%（38/44）， including 86.84%（33/38）accepting the D2 lymph node excisio