聚维酮碘消毒液的毒性研究_张紫虹.pdfVIP

2008 8 18 8 Ch inese J urnal fH ea lth Lab rat ry Techn l gy, Aug 2008; V l 18 N 8 1641 = 聚维酮碘消毒液的毒性研究 张紫虹, 杨美玲, 胡永成, 谭建斌, 李志 (, 510300) [ ] : : : LD 5000 mg /kg# BW, ; 50 , 4; , ; , 1000 m g/kg# BW , , , : , , [ ] 聚维酮碘; 急性毒性; 亚急性毒性; 微核试验; 刺激性 [ ] R 114 [] B [] 1004- 8685( 2008) 08- 1641- 03 Toxicity of povidone iodine disinfection solution Zhang Z i-hong, Yang M ei-ling, H u Yong-cheng, Tan J ian-b in, L i Zh i ( Guangd ng Center f rD isease C ntr l and Preventi n, Guangzh u 510300, Ch ina) [ Abstract] Objective: T evaluate the t x ic l gical safety f p vid ne i dine d isinfecti n s luti n1M ethods: A cc rding t the technical standard f r d is infecti n, the acute ral t x icity test, the subacute t x icity test, them icr nucleus test, and the acute eye and derm al irritati n test were perf rm ed1Results: The LD50 f p vid ne i dine d is infecti n s luti n f r b th rats and m ice were m re than 5000 mg /kg# BW1 In the ey e and derm al irritati n tests, the st ck s luti n sh w ed n irritati n n eyes, in tact sk ins and dam aged sk ins f rabb its1 L w irritati n w as bserved in regular vaginalmuc sa test1The resu lt f them use b nem arr w p l- ychr m atic erythr cytes ( PCE ) m icr nucleus test w as negative1 C m pareed w ith the c ntr l gr up, the b dy w eigh t, rgan c effi- cient and lab rat ry exam inati ns in d ifferen t d sage gr ups( 1000 mg/ kg# BW ) sh w ed n sign ifican t d ifferences1N bvi us path l gical changes f vari us rgans w ere bserved in the tested an mi als1Conclusion: The p vid ne i d ine d is infecti n s luti n in given d sages is t x ic l gi